Cisplatin bonded to guanine

Author: mrek

August undefined, 2024

WebIt has bond angles of 90 °. Cisplatin has two chloride ions and two ammonia molecules as ligands. The overall charge on cisplatin is zero, this is because the charge on the ... in cisplatin is replaced by a nitrogen atom on a guanine base, which forms a bond with the platinum ion in cisplatin. Oxaliplatin is another platinum based anticancer ... WebPart 1: exploring the structure of cisplatin. Cisplatin contains a central Pt ion with four ligands. The two chloride ligands can undergo ligand substitution to allow cisplatin to …

Cisplatin and drug design - RSC Education

WebJun 2, 2008 · NMR and X-ray structural characterization of a cisplatin analogue able to slow down the Pt-N7 rotation of a coordinated guanine base by a billion-fold times: 2,2'-bipiperidine (dimethylmalonato)platinum (II) complex Authors Francesco P Intini 1 , Renzo Cini , Gabriella Tamasi , Michael B Hursthouse , Giovanni Natile Affiliation WebDec 1, 2003 · When adenine binds, only a weak hydrogen bond forms between the chloride ligand of cisplatin and the H (2)N-C6 group of adenine. Second, a significantly stronger molecular orbital interaction... theoretical models of the body

Cisplatin - CHEMISTRY COMMUNITY

WebThe bonding energies between Cisplatin and the target molecules were performed. Cisplatin forms the strongest bonds with Guanine and Pyridoxal phosphate (vit.B6). The vibrations of Pt-N7 bond in complexes occur in the low range of frequencies with low intensities. Only in case of nucleobases appeared vibrations of Pt-N 7 in high frequencies. WebJul 7, 2015 · The bonded cisplatin molecule may have its second arm bond to a neighboring guanine or adenine base, forming a di-adduct (see the schematic image in … WebApr 13, 2016 · Five moieties are coordinated by the N7-atoms of guanine bases at positions G1300 of the 16S rRNA and G27, G425, A1606, G2220, G2221 of the 23S rRNA (Figure 1, Supplementary Figure S1). One cisplatin moiety is coordinated by the N-terminus of the ribosomal protein L9 (Figure 1I). A small total number of the cisplatin binding sites in the ... theoretical musings

Interaction of cisplatin with adenine and guanine: a combined ... - PubMed

Effect of cisplatin binding on guanine in nucleic acid: an …

WebMar 1, 2006 · On the left, cisplatin has formed a crosslink between two neighboring guanine bases, causing the DNA double helix to bend around the site of damage. This … WebCisplatin is a chemotherapy medication used to treat a number of cancers. [2] These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck cancer, esophageal cancer, lung cancer, … theoretical moles of alcl3 produced molWebStudy with Quizlet and memorize flashcards containing terms like DNA must be _____ _____ when cells divide, How does DNA replicate itself ?, Why are the covalent bonds unaffected when DNA copies itself ? and more. theoretical models of psychology

"WebCisplatin is a substance used to treat some forms of cancer. Inside cells, each cisplatin molecule forms two chemical bonds with a DNA molecule. The diagram shows part of a DNA molecule with cisplatin attached. Name A and B. The nitrogenous bases. Both bonds form with the same base. " - Cisplatin bonded to guanine

Cisplatin bonded to guanine

Cisplatin and drug design - RSC Education

WebSep 24, 2024 · The cisplatin molecule hydrolyzes in the cytoplasm, and acts as a potent electrophilic agent, reacting with nucleic acids and sulfhydryl groups of proteins [14,15]. However, the therapeutic target of this drug is genomic and mitochondrial DNA. WebJan 30, 2013 · In agreement with computational results, the IR characterization of cis- [Pt (NH (3)) (2) (G)Cl] (+) points to a covalent structure where Pt is bound to the N7 atom of …

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WebDec 1, 2003 · The pH- and time-dependent reaction of the anticancer drug carboplatin, [Pt (cbdca-kappa (2)O,O') (NH (3)) (2)] (cbdca=cyclobutane-1,1-dicarboxylate), with the tripeptides H-glyglymet-OH (glycylglycyl-L-methionine) and Ac-glyglymet-OH at 313 K was investigated by high-performance liquid chromatography, NMR and mass spectrometry. WebThe most favorable position on DNA base to react with cisplatin is the N7 site of deoxyguanosine residue. Cisplatin forms only one covalent bond with DNA at first, …

Web(a) The structure of cisplatin (with platinum shown in green and nitrogen ligands shown in blue) coordinated to a dinucleotide containing two guanines. Notice the destacking of …

WebJan 24, 2005 · This in turn means that the known stability of cisplatin-guanine complexes cannot be ascribed solely to hydrogen bonding and allows decomposition of total binding energy into contributions from covalent and hydrogen bonds. WebOct 28, 2003 · Abstract. The thermodynamics and kinetics for the monofunctional binding of the antitumor drug cisplatin, cis …

WebNov 10, 1997 · The first is shifting the keto-enol tautomerization of guanine towards the enol form (rare in DNA) in the presence of cisplatin. The second is the action of cisplatin on the guaninecytosine pairing in DNA through binding to the O6 site of guanine which is involved in one of three hydrogen bonds between these nucleic bases.

WebDec 7, 2024 · When it binds to the guanine base on the DNA molecule, a chlorine is released from cisplatin and binds to a lone pair on the guanine. Since there are two … theoretical moment of inertiaWebJan 24, 2005 · Ab initio and density functional calculations are employed to investigate the role of hydrogen bonding in the binding of cisplatin to the purine bases guanine and … theoretical mw kdaWebThe positively charged products of Cisplatin hydrolysis can form bonds with Guanine and Adenine, showing the ability to crosslink with nucleobases within the double helical DNA, … theoretical movementsWebNov 10, 1997 · We propose that cisplatin binding to guanine in DNA leads to a point mutation as the latter is the only change that the nucleic acid could "remember" … theoretical myth of samenessWebTests involving the action of cisplatin on a guanine-like structure (1,3,9-trimethylxanthine), showed it to bind at N 7 and not O 6. Further studies revealed cisplatin to preferrentially bind at N 7 of the purines adenine … theoretical narrativeWebJul 19, 2024 · Cisplatin prevents DNA replication in cancer cells by a ligand replacement reaction with DNA in which a bond is formed between platinum and a nitrogen atom on guanine. Students should be able to: explain … theoretical most efficient solar panelsWebDec 23, 2004 · This in turn means that the known stability of cisplatin−guanine complexes cannot be ascribed solely to hydrogen bonding and allows decomposition of total binding … theoretical movement concepts