Cisplatin transporter

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WebMar 20, 2024 · Cisplatin is a substrate of hOCT1 ( SLC22A1 ), hOCT2 ( SLC22A2 ), and hMATE1 ( SLC47A1 ), and oxaliplatin is a substrate of hOCT2, hOCT3 ( SLC22A3 ), hMATE1 ( SLC47A1 ), and hMATE2-K ( … WebThe direction of MATE1 transport is defined by the proton concentration gradient: when assayed in vitro at pH 7.4 or higher, MATE1 behaves as an uptake transporter, whereas …

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WebApr 30, 2015 · Cisplatin is one of the first-line platinum-based chemotherapeutic agents for treatment of many types of cancer, including ovary cancer. CTR1 (copper transporter 1), a transmembrane solute carrier transporter, has previously been shown to increase the cellular uptake and sensitivity of cisplatin. It is hypothesized that increased CTR1 … WebIn addition, cisplatin is the standard treatment of patients with non-small cell lung cancer (NSCLC) when druggable mutations are not present in the tumour 34. Hence, Pt drugs have not been... firstsite free school meals

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WebThe copper transporter 1 seems to be of particular importance for cisplatin uptake in tumor cells, while the organic cation transporter (OCT) 2, due to its specific organ distribution, may play a major role in the development of undesired cisplatin side effects. WebHydroxytyrosol protects against cisplatin-induced nephrotoxicity via attenuating CKLF1 mediated inflammation, and inhibiting oxidative stress and apoptosis. ... of cisplatin in suppression of hepatocellular carcinoma via inhibiting CKLF1 mediated NF-κ B pathway and regulating transporter mediated drug efflux. Journal of Ethnopharmacology, 2024 ... WebSep 15, 2024 · DESCRIPTION. Cisplatin Injection (cisplatin injection (cisplatin (cisplatin injection) injection) ) is a sterile aqueous solution, available in 50, 100 and 200 mL … campaigning mindset

The copper transporter ctr1 and cisplatin accumulation at the …

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WebCisplatin is mainly internalised by the copper transporter CTR1. Accordingly, CTR1 down-regulation has been associated with resistance to platinum-based drugs in cancer [ 10 , 11 ]. Cellular inactivation of cisplatin and subsequent sequestration can be mediated by binding to cytoplasmic nucleophilic factors, including glutathione (GSH) and ... campaigning groupWebDec 14, 2024 · Cisplatin (CDDP) is a chemotherapy drug commonly used in systemic treatment of germ cell tumors, including cancers of the ovaries, testes, and solid tumors of the head and neck 1. campaigning in fur coat

"WebJul 1, 2024 · The remaining cisplatin can transport to tumor cells by passive diffusion through plasma membrane [31], [44], [47]. Modern studies reveal that copper transporter protein CTR1 is also responsible for cisplatin uptake [48]. Cisplatin causes degradation of concentration of CRT1, resulting in lower cisplatin accumulation by the cancer cells. " - Cisplatin transporter

Cisplatin transporter

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WebMay 17, 2024 · They postulated that cisplatin could compete with copper for CTR1-mediated transport, but did not further investigate the consequences on copper homeostasis or potential modification of CTR1. Platinum coordination may also alter conformation or block necessary amino acids for native Cu (I) interactions. WebJul 22, 2009 · Organic cation transporter 2 (OCT2) has been implicated in the cellular uptake of cisplatin, but its role in cisplatin-induced nephrotoxicity remains unknown. In mice, deletion of Oct1 and Oct2 resulted in significantly impaired urinary excretion of cisplatin without an apparent influence on plasma levels.

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WebApr 14, 2024 · HIGHLIGHTS. who: ICP-TOF et al. from the Autonomous University of Madrid, Spain have published the research: The copper transporter CTR1 and cisplatin … WebApr 14, 2024 · Flavonoids are enriched in various vegetables, fruits, and herbal products, and some were reported to produce transporter-mediated DDIs. This study aimed to screen potential inhibitors of OCT2 from 96 flavonoids, assess the nephroprotective effects on cisplatin-induced kidney injury, and clarify the structure-activity relationships of ...

WebApr 5, 2024 · Cisplatin is a platinum containing drug first approved as an antineoplastic agent in 1978. It remains an important and effective therapy in many forms of cancer today. Cisplatin mediates its tumorcidal effects via a number of different cytotoxic mechanisms. Although it is best known for DNA damage, cisplatin also causes cytoplasmic organelle … WebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, ... membrane-bound mechanosensitive sodium …

WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 cells, either induced by cisplatin or by UV light, can lead to further apoptotic death in … Web(mate1) mediate cellular transport of cisplatin. Transporter mediated uptake has been shown to be an important process mediating cellular accumulation of cisplatin. Cisplatin is one of the most widely utilized antitumor drugs in the world [6]. Cisplatin was the first platinum-based drug that revolutionized the treatment of neoplastic diseases.

WebNov 15, 2024 · Magnesium co-administration decreases cisplatin-induced nephrotoxicity in the multiple cisplatin administration Life Sci. 2024 Nov 15;189:18-22. doi: 10.1016/j ... Expression of renal organic cation transporter 2 (rOct2) and multidrug and toxin extrusion protein 1 (rMate1), which are involved in CDDP transport, did not differ between the …

WebSep 6, 2012 · Cisplatin is a potent cytostatic drug, whose use is limited by its severe acute and chronic nephro-, oto-, and peripheral neurotoxicity. For this reason, other platinum derivatives, such as carboplatin and oxaliplatin, with less toxicity but still with antitumoral action have been developed. campaigning it\u0027s a process icivicsWebJul 3, 2024 · Cisplatin is widely used for the treatment of a number of solid malignant tumors. However, ototoxicity induced by cisplatin is an obstacle to effective treatment of tumors. The basis for this toxicity has not been … campaigning near polling place gaWebApr 26, 2024 · Full article: Update on drug-drug interaction at organic cation transporters: mechanisms, clinical impact, and proposal for advanced in vitro testing Expert Opinion on Drug Metabolism & Toxicology Volume 17, 2024 - Issue 6 Open access 2,926 Views 2 CrossRef citations to date 0 Altmetric Listen Review campaigning in the philippinesWebSep 18, 2024 · NCBI Bookshelf firstsite holiday funWebCisplatin triggers rapid degradation of Copper Transporter 1, reducing influx of cisplatin and increasing resistance to it. Explore the transporter in PDB ID 6m97 . Glutathione transferase (GST) P1-1 is a cisplatin-binding protein that can inactivate cisplatin. campaigning on county property in texasWebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in … campaigning novelistWebOct 7, 2002 · Cisplatin is a chemotherapeutic drug used to treat a variety of cancers. Both intrinsic and acquired resistance to cisplatin, as well as toxicity, limit its effectiveness. … campaigning means