Cth522
WebAug 13, 2024 · CTH522:CAF01 showed additional signs of better performance compared with CTH522:AH including an enhanced mucosal antibody profile that serves as first line of defence against the infection, and a ... WebSep 2, 2024 · The recombinant antigen CTH522 is a version of the major outer membrane protein of C. trachomatis, which has shown promising results in animal vaccination studies.
Cth522
Did you know?
WebAug 30, 2024 · CTH522:CAF01 had a stronger immunogenicity response than CTH522:AH, showing its potential as a leading chlamydia vaccine candidate. Following the promising safety data from this Phase I trial, CTH522:CAF01 demonstrated an enhanced mucosal antibody with increased immunoglobulin G (IgG) titers, accelerated seroconversion, and … WebApr 24, 2024 · This trial is a phase I, double-blind, parallel, randomised, and placebo-controlled trial of the chlamydia vaccine CTH522 in healthy adults. It is planned to …
WebFeb 10, 2024 · The mucosal responses were characterized by CTH522-specific IgG/IgA antibodies, together with CTH522-specific interferon γ-producing Th1 cells. This study demonstrates that mucosal administration of CTH522 adjuvanted with chitosan-coated LPNs represents a promising strategy to modulate the magnitude of mucosal vaccine responses. WebOct 1, 2024 · CTH522 adjuvanted with either CAF01 or aluminium hydroxide appears to be safe and well tolerated. Both vaccines were immunogenic, although CTH522:CAF01 had …
WebCTH522 adjuvanted with either CAF01 or aluminium hydroxide appears to be safe and well tolerated. Both vaccines were immunogenic, although … WebApr 19, 2024 · Our CTH522 vaccine, which has recently completed clinical phase I trial 34, targets the prevalent SvD, E, F, and G with surface-binding and -neutralizing antibodies. …
WebFeb 10, 2024 · The mucosal responses were characterized by CTH522-specific IgG/IgA antibodies, together with CTH522-specific interferon γ-producing Th1 cells. This study demonstrates that mucosal administration of CTH522 adjuvanted with chitosan-coated LPNs represents a promising strategy to modulate the magnitude of mucosal vaccine responses.
WebDec 11, 2024 · Highly committed and result-oriented with 20 years of solid scientific experience from academia and industry. Strong competences in formulation and drug delivery. Motivated by taking responsibilities and solving new challenges using creative and strategic mindset. Skills and experience in team. First author and Co-author in 16 … fitting a thermostatic shower barWebJan 23, 2024 · The vaccine consisted of the C.t. vaccine antigen CTH522, 31,32 formulated in the adjuvant CAF01 (cationic adjuvant formulation 01), which possess a unique property of inducing circulating Th1 T ... fitting a tapered gibWebFeb 13, 2024 · In the native state, CTH522 did not exist as a monomer, but showed an unusual self-assembly into nanoparticles with a negative zeta-potential. In contrast to the β-barrel structure of MOMP ... fitting a thermostatic shower valveWebAug 12, 2024 · report the safety and immunogenicity results from the first phase 1 study of a genital C trachomatis vaccine candidate, CTH522, containing engineered heterologous immunorepeats from segments of the chlamydial major outer membrane protein (MOMP). Participants received CTH522 adjuvanted with either liposomal CAF01 or aluminium … can i get a 65 tv in uber suvWebThe trial aimed to assess the safety and ability to provoke an immune response of the CTH522 chlamydia vaccine. 35 women not infected with chlamydia were included in the trial. The trial included two adjuvants and a saline control group. The vaccine was found to be safe, and all women who received the vaccine regardless of adjuvant developed an ... can i get a 6 month broadband contractWebAug 12, 2024 · Of note, though both vaccines showed significant efficacy, CTH522:CAF01 demonstrated a reliably superior, though non-statistically significant difference in immunogenicity compared with CTH522:AH. After the third administration in the vaccine series, CTH522:CAF01 induced a 5.6-fold higher median titer compared with … fitting a thermostat for central heatingWebThe most advanced vaccine against infection with C. trachomatis is the CTH522 vaccine. The vaccine antigen CTH522 is a recombinant, engineered version of the C. trachomatis major outer membrane protein (MOMP), comprising heterologous immunorepeats from four genital C. trachomatis serovars (D, E, F, and G). fitting a stormguard threshold