WebJul 7, 2024 · The obtained results clearly indicated the possibility that endogenous LDL particles can assist the targeting of the squalenoylated Gem toward the high LDLR-expressing MDA-MB-231 cells. The high tendency of this tumor to accumulate LDL particles was confirmed by the dosage of the circulating LDL-cholesterol before and after the … WebJul 5, 2024 · Abstract. Selective delivery of anticancer drugs to rapidly growing cancer cells can be achieved by taking advantage of their high receptor-mediated uptake of low-density lipoproteins (LDLs). Indeed, we have recently discovered that nanoparticles made of the squalene derivative of the anticancer agent gemcitabine (SQGem) strongly interacted ...
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WebOriginal Article Circulating Lipoproteins: A Trojan Horse Guiding Squalenoylated Drugs to LDL-Accumulating Cancer Cells Dunja Sobot, 1Simona Mura, Marie Rouquette,1 Branko Vukosavljevic,2 Fanny Cayre, Eric Buchy, Grégory Pieters, 3Sébastien Garcia-Argote, Maike Windbergs,2,4 Didier Desmaële,1 and Patrick Couvreur1 1Institut Galien Paris-Sud, UMR … WebOct 15, 2010 · Squalenoyl-gemcitabine/edelfosine nanoassemblies: Anticancer activity in pediatric cancer cells and pharmacokinetic profile in mice 2024, International Journal of Pharmaceutics Show abstract Polymeric modification of gemcitabine via cyclic acetal linkage for enhanced anticancer potency with negligible side effects 2024, Biomaterials …
WebDec 5, 2024 · Abstract. Raman scattering is one of the most used spectroscopy and imaging techniques in cancer nanomedicine due to its high spatial resolution, high chemical specificity, and multiplexity modalities. The flexibility of Raman techniques has led, in the past few years, to the rapid development of Raman spectroscopy and imaging for ... WebSqualene monooxygenase uses NADPH and molecular oxygen to oxidize squalene to 2,3-oxidosqualene (squalene epoxide) (Fig. 1 ). This reaction is the first oxygen-dependent step in cholesterol biosynthesis and is thought to be the second rate-limiting step ( Gill et al., 2011 ). The transcription of squalene monooxygenase is controlled by SREBP in ...
Webdemonstrate that the squalenoylated doxorubicin nanoassemblies make tumor cells more sensitive to doxorubicin and reduce the cardiac toxicity. Author contributions: A.M., F.D., and P.C. designed research; A.M., F.D., J.M., A.F., S.W., L.H.R., A.-A.W., E.L., C.B., B.S., and L.C. performed research; A.M., F.D., L.C., and P.C. WebJul 1, 2013 · This concept, termed “squalenoylation”, has been applied to natural nucleosides such as thymidine, to anticancer nucleoside analogues such as gemcitabine and cytarabine, as well as to the antiviral NRTIs azidothymidine (AZT, zidovudine), didanosine (ddI) and dideoxycytidine (ddC, zalcitabine).
WebApr 19, 2012 · We describe here new nanoparticles based on the bioconjugation of penicillin G to squalene in order to overcome severe intracellular infections by pathogen bacteria whose mechanism of resistance arises from the poor intracellular diffusion of …
WebSqualenoylation of NOTA enabled in vivo monitoring of SqGem-based NP pharmacokinetics and biodistribution. Conclusion: We present a scalable technique for fabricating efficacious squalenoylated-gemcitabine … how old is andrea mitchell of msnbcWebNanotechnology offers many possibilities to improve drug treatments, including with regard to drug pharmacology. The current study reports a simple approach to improve cisplatin efficacy in the treatment of colon cancer through the creation of orally administered squalenoylated nanoparticles loaded with cisplatin (SQ-CDDP NP). mercer co animal shelter princeton wvWebMay 31, 2024 · Nanotechnology offers many possibilities to improve drug treatments, including with regard to drug pharmacology. The current study reports a simple approach to improve cisplatin efficacy in the treatment of colon cancer through the creation of orally administered squalenoylated nanoparticles loaded with cisplatin (SQ-CDDP NP). how old is andrea perronWebJul 20, 2012 · Squalene is a triterpene widely distributed in nature that is an intermediate in the cholesterol biosynthesis pathway. The remarkable dynamic folded conformation of squalene has been used to chemically conjugate this lipid with various therapeutic molecules to construct nanoassemblies of 100–300 nm. In this review, we discuss the … how old is andrea mitchell reporterWebApr 19, 2012 · The squalenoylated nanoparticles were found to be cell internalized through clathrin-dependent and -independent endocytic pathways. Moreover, they induced an improved intracellular antibacterial activity on the facultative intracellular pathogen S. aureus , compared with free penicillin G, despite the absence of co-localization between the ... mercer co ky circuit court clerkWebsqualenoylated. simple past tense and past participle of squalenoylate; Adjective . squalenoylated (not comparable) Modified by addition of a squalenoyl group how old is andre arlovskiWebSeveral ecdysteroid acetonides act as adjuvant chemo-sensitizing agents against various cancer cell lines, and they can be formulated to self-assembling nanoparticle (NP) pro-drugs through a hydrolysable conjugation with squalene. In the bloodstream such squalenoylated nanoparticles dissolve into low-density lipoprotein (LDL) that allows targeting tissues … how old is andrea navedo