WebNesprins are large multi-domain proteins that link the nuclear envelope to the cytoskeleton and nucleoskeleton. Here we show that nesprin-1 and nesprin-2 play important roles in … WebSYNE2. On the top, protein expression in current human tissue, based on all annotated cell types, is reported with the units not detected (n), low (l), medium (m) and high (h). …

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WebMay be involved in nucleus-centrosome attachment and nuclear migration in neural progenitors implicating LINC complex association with SUN1/2 and probably association … WebIn venous microvessels, where most studies have focused, the ESL is approximately 0.5 µm in thickness. Of that, only 50 nm is demonstrably comprised of organic molecules: a predominately polysaccharide mixture of heparan and chondroitin sulfates extending out from the endothelial membrane surface, with hyaluronic acid (HA) loosely associated … how to modernize old dining room chairs

Nesprin-1 and nesprin-2 regulate endothelial cell shape and

WebHuman SYNE2 KO cell line was engineered from HAP1 by CRISPR/Cas9 technology to contain a frameshift mutation in a coding exon. Glow Biologics can also help you to make the ko cell lines from other host cell lines. Web29 p.E303del) and one or two copy of SYNE2 gene (c.1721T>C, c.12001T>C, and c.12002G>A), 30 encoding I574T, W4001R, and W4001Ter variants. We propose that these SYNE2 variants are linked 31 to earlier disease onset in this patient by impacting the protein-protein interaction between TOR1A and 32 SYNE2. WebA number sign (#) is used with this entry because of evidence that Emery-Dreifuss muscular dystrophy-5 (EDMD5) is caused by heterozygous mutation in the SYNE2 gene ( 608442) on chromosome 14q23. For a discussion of genetic heterogeneity of EDMD, see 310300. multivers online.nl