WebIntroduction. Mutations in the acid β-glucocerebrosidase (GBA1) gene cause the lysosomal storage disease Gaucher’s disease (GD), which is an autosomal recessive condition that can present with both systemic and neurological symptoms.Three clinical GD subtypes have been identified: nonneuropathic (type I), acute neuropathic (type II), and chronic … WebNov 28, 2013 · We report the simultaneous imaging of protonated and deprotonated forms of carbonylcyanide p-trifluoromethoxy-phenylhydrazone (FCCP) molecules in live cells by …
Full article: Regulation of PRKN-independent mitophagy - Taylor
WebCarbonyl cyanide-4-(trifluoromethoxy)phenylhydrazone (FCCP) is a proton (H +) ionophore and a potent mitochondrial uncoupling agent.This compound turns the mitochondrial membrane permeable to protons, thus dissipating the mitochondrial membrane potential and uncouples oxidative phosphorylation from ATP synthesis. Web杭州海瑞化工有限公司 Cas 370-86-5,Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone;HR182141. downsizing vf streaming
Phenylhydrazone Sigma-Aldrich
WebThe EARS2 nuclear gene encodes mitochondrial glutamyl-tRNA synthetase, a member of the class I family of aminoacyl-tRNA synthetases (aaRSs) that plays a crucial role in mitochondrial protein biosynthesis by catalyzing the charging of glutamate to mitochondrial tRNA(Glu). Pathogenic EARS2 variants have been associated with a rare mitochondrial … Web해서 화공 Cas 370-86-5,Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone;HR182141. WebFeb 11, 2024 · Figure 1. Molecular mechanisms of PRKN-independent mitophagy. De novo autophagosome formation can take place near the ER from various membrane sources or at/around the cargo. Autophagy initiation requires the activation of ULK1 complex that is tightly regulated by MTORC1 and AMPK and series of phosphorylation events triggered by … downsizing upsizing rightsizing