Triphenylphosphonium cation

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August undefined, 2024

WebFeb 5, 2024 · As a lipophilic cation, triphenylphosphonium (TPP) has been commonly used in designing mitochondria‐targeted antioxidants. Conjugated with the TPP moiety, antioxidants can achieve more than 1000‐fold higher mitochondrial concentration depending on cell membrane potentials and mitochondrial membrane potentials. Herein we discuss … WebFeb 19, 2015 · One of the most useful strategies in targeting molecules to mitochondria consist of the conjugation of drugs and bioactive molecules to lipophilic cations such as triphenylphosphonium (TPP), because they can rapidly cross phospholipid bilayers without requiring a transporter and can be easily taken up into mitochondria [9].

Phosphonium - Wikipedia

WebJan 5, 2024 · The triphenylphosphonium cation was used as an efficient means for selective delivery of known anticancer agents such as doxorubicin (Han et al. 2014) and … WebFeb 23, 2007 · The cations lie in general positions except for A where the 1,2-bis (triphenylphosphonium)ethane cation lies at the centre of symmetry. It seems that for all the cations the description of the triphenylphosphonium moiety conformation (-PPh 3) the model reported by Dance & Scudder 14 could be useful. mona in the promised land gish jen

Comparison of 18F-Labeled Fluoroalkylphosphonium Cations with …

WebJan 1, 2004 · Triphenylphosphonium cations with hydrophobic alkyl chains interact with phospholipid bilayers in a similar way to TPP, with the triphenylphosphonium cation binding to the same location in the membrane. 5 The more-hydrophobic compounds adsorb to the membrane surface to a greater extent because of the entropic driving force of … WebPhosphonium. 15 languages. Edit. Structure of PH+. 4, the parent phosphonium cation. In polyatomic cations with the chemical formula P R+. 4 (where R is a hydrogen or an alkyl, aryl, or halide group). These cations have tetrahedral structures. The salts are generally colorless or take the color of the anions. monai randrotated

Novel Mitochondria-Targeted Triphenylphosphonium Conjugates …

Triphenylphosphonium cation: A valuable functional group

WebOct 21, 2024 · Methods: The mitochondriotropic polymer TPP-PEG-PE was synthesized for the preparation of PUE@TPP /PEG-PE micelles modified with triphenylphosphonium (TPP) cation. The physicochemical properties and anti-apoptosis effect of PUE@TPP /PEG-PE micelles were investigated. The coumarin 6 (C6)-labeled TPP/PEG-PE ( C6@TPP /PEG-PE) … WebThus, the triphenylphosphonium functional group should be considered for the development of photoantimicrobials for the selective killing of Gram-positive bacteria in the presence of … ian tyson horsethief moonWebOct 21, 2007 · Mitoquinone is targeted to mitochondria by covalent attachment to a lipophilic triphenylphosphonium cation. Because of the large mitochondria membrane potential, the cations accumulate within cellular mitochondria up to 1,000 fold, compared to non-targeted antioxidants such as Coenzyme Q or its analogues, enabling the antioxidant … ian tyson m c horses

"WebJun 13, 2024 · The first radiolabeled phosphonium cation studied for use in PET was [ 11 C]triphenylmethylphosphonium ( [ 11 C]TPMP ) [ 13 ]. [ 11 C]TPMP PET studies were performed to evaluate the membrane potential of heart tissue in canine models, which was determined to be 148.1 ± 6.0 mV (inside negative). " - Triphenylphosphonium cation

Triphenylphosphonium cation

Delivery of bioactive molecules to mitochondria in vivo PNAS

WebMay 11, 2024 · The lipophilic triphenylphosphonium cation is capable of accumulating in the mitochondrial matrix, proportionally to the difference in the potential present within the mitochondria, which makes it especially interesting to use in overactive mitochondria with increased potential, such as tumor cells ( Reily et al., 2013 ). WebJun 2, 2011 · Triphenyl phosphonium cations (TPPs) are delocalized lipophilic cations that accumulate in the mitochondria of cells. We have explore the effect of increasing the …

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WebHere, we describe protocols dealing with the preparation, mitochondria permeation assessment, electron paramagnetic resonance (EPR) spin trapping setting, and antiapoptotic properties evaluation of a series of new linear nitrones vectorized by a triphenylphosphonium cation and labeled with a diethoxyphosphoryl moiety as 31 P … WebApr 30, 2015 · Lipophilic cations based on the triphenylphosphonium moiety (TPP +) have been widely used to target various biologically active substances such as antioxidants …

WebMicelles Loaded With Puerarin And Modified With Triphenylphosphonium Cation Possess Mitochondrial Targeting And Demonstrate Enhanced Protective Effect Against Isoprenaline-Induced H9c2 Cells Apoptosis WebJul 1, 2008 · The use of the TPP cation to increase the antioxidant defences of mitochondria has been demonstrated to be a viable strategy in vitro. It has also been shown that …

WebAug 9, 2024 · Triphenylphosphonium-based modification of molecules facilitating mitochondria targeting is not a totally new concept as abundant literature already exists with regard to the potent biological effects exhibited by small molecules containing TPP +.28,32,33,40–44 Alkylated triphenylphosphonium cations initially were used as probes to … WebOne way to do this is to invent antioxidants that are selectively accumulated into mitochondria within patients. Such mitochondria-targeted antioxidants have been developed by conjugating the lipophilic triphenylphosphonium cation to an antioxidant moiety, such as ubiquinol or α-tocopherol.

WebApr 15, 2003 · Because alkyltriphenylphosphonium cations pass easily through lipid bilayers by non-carrier-mediated transport, they should be taken up by the mitochondria of all …

WebNov 30, 2024 · Here we present a method for identification of PEPSs, and show that conjugation with mitochondria-targeting triphenylphosphonium cation (TPP +) can enhance or restore the compounds' antifungal activity. mona in the promised land summaryWebSep 1, 2024 · Triphenylphosphonium cation (TPP +), mitochondrial homing moiety with high lipophilicity, served as the frequently-used targeted moiety. For example, by attaching TPP+ as the mitochondrial homing moiety to α-tocopherol succinate, mito-vitamin E was shown to overcome drug resistance in lung carcinoma [17]. ian tyson live at longviewWebLipophilic cations such as phosphonium salts penetrate the hydrophobic barriers of the plasma and mitochondrial membranes and accumulate in mitochondria in response to … ian tyson great speckled bird rarWebConjugating conventional mitochondrial-targeted antioxidants, such as coenzyme Q10 or vitamin E, with the lipophilic triphenylphosphonium cation significantly increases the mitochondrial availability of these antioxidants, delivered as MitoQ or MitoVitE (Kalra, 2024). MitoQ (mitoquinone mesylate) was shown to penetrate to the IMM and improve ... mona in the promised landWebA series of novel triphenylphosphonium (TPP) cations of the diterpenoid isosteviol (1, 16-oxo-ent-beyeran-19-oic acid) have been synthesized and evaluated in an in vivo … ian tyson live at longview youtubeWebOct 1, 2015 · Thus, 18F-labeled fluoroalkylphosphonium derivatives (18F-FATPs), including (5-18F-fluoropentyl)triphenylphosphonium cation (18F-FPTP), (6-18F-fluorohexyl)triphenylphosphonium cation (18F-FHTP), and (2-(2-18F-fluoroethoxy)ethyl)triphenylphosphonium cation (18F-FETP), were synthesized. The … ian tyson love songsWebOct 19, 2016 · The lipophilic triphenylphosphonium cation (TPP) has been the most widely used to direct a range of moieties to mitochondria in vivo, including redox probes, antioxidants and spin traps [ 2, 4, 5 ]. The TPP moiety is relatively easy to introduce into a compound by displacing a leaving group by reaction with triphenylphosphine [ 6 ]. ian tyson navajo rug chords